Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

• Autores principales: Wenfeng Lin (Autor), Jiaqi Xiong (Autor), Yefan Jiang (Autor), Hao Liu (Autor), Jinhui Bian (Autor), Juejin Wang (Autor), Yongfeng Shao (Autor), Buqing Ni (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of M...