Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes.

• Main Authors: Radoslaw P Kozak (Author), Karina Mondragon-Shem (Author), Christopher Williams (Author), Clair Rose (Author), Samirah Perally (Author), Guy Caljon (Author), Jan Van Den Abbeele (Author), Katherine Wongtrakul-Kish (Author), Richard A Gardner (Author), Daniel Spencer (Author), Michael J Lehane (Author), Álvaro Acosta-Serrano (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which reduces its anti-hemostatic and anti-clotting properties. To bett...