Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.

• Main Authors: Daniel P Depledge (Author), Lorna M MacLean (Author), Michael R Hodgkinson (Author), Barbara A Smith (Author), Andrew P Jackson (Author), Saufung Ma (Author), Silvia R B Uliana (Author), Deborah F Smith (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and...