Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach
Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study...
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Hindawi Limited,
2015-01-01T00:00:00Z.
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