Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

• मुख्य लेखकों: Misbah Misdaq (लेखक), Sonia Ziegler (लेखक), Nicolas von Ahsen (लेखक), Michael Oellerich (लेखक), Abdul R. Asif (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2015-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study...