Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome

• Main Authors: Antonella Tramutola (Author), Simona Lanzillotta (Author), Giuseppe Aceto (Author), Sara Pagnotta (Author), Gabriele Ruffolo (Author), Pierangelo Cifelli (Author), Federico Marini (Author), Cristian Ripoli (Author), Eleonora Palma (Author), Claudio Grassi (Author), Fabio Di Domenico (Author), Marzia Perluigi (Author), Eugenio Barone (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer's disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies from our group showed an early accumulation of...