Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome

• Главные авторы: Antonella Tramutola (Автор), Simona Lanzillotta (Автор), Giuseppe Aceto (Автор), Sara Pagnotta (Автор), Gabriele Ruffolo (Автор), Pierangelo Cifelli (Автор), Federico Marini (Автор), Cristian Ripoli (Автор), Eleonora Palma (Автор), Claudio Grassi (Автор), Fabio Di Domenico (Автор), Marzia Perluigi (Автор), Eugenio Barone (Автор)
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• Опубликовано: MDPI AG, 2023-01-01T00:00:00Z.
• Предметы: article
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Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer's disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies from our group showed an early accumulation of...