NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

• Main Authors: Mahmoud Taha (Author), Essam A. Assali (Author), Tsipi Ben-Kasus Nissim (Author), Grace E. Stutzmann (Author), Orian S. Shirihai (Author), Michal Hershfinkel (Author), Israel Sekler (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hepatic Ca2+ signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca2+ signaling and their contribution to metabolic activity remain, however, poorly understood. Moreover, the molecular mechanism governing the...