NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

• Auteurs principaux: Mahmoud Taha (Auteur), Essam A. Assali (Auteur), Tsipi Ben-Kasus Nissim (Auteur), Grace E. Stutzmann (Auteur), Orian S. Shirihai (Auteur), Michal Hershfinkel (Auteur), Israel Sekler (Auteur)
• Format: Livre
• Publié: Elsevier, 2024-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Hepatic Ca2+ signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca2+ signaling and their contribution to metabolic activity remain, however, poorly understood. Moreover, the molecular mechanism governing the...