Whole-exome sequencing reveals potential mechanisms of drug resistance to FGFR3-TACC3 targeted therapy and subsequent drug selection: towards a personalized medicine

• Main Authors: Zhou Tong (Author), Cong Yan (Author), Yu-An Dong (Author), Ming Yao (Author), Hangyu Zhang (Author), Lulu Liu (Author), Yi Zheng (Author), Peng Zhao (Author), Yimin Wang (Author), Weijia Fang (Author), Feifei Zhang (Author), Weiqin Jiang (Author)
• Format: Book
• Published: BMC, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Drug resistance is a major obstacle to effective cancer therapy. In order to detect the change in tumor genomic states under drug selection pressure, we use next-generation sequencing technology to investigate the underlying potential mechanisms of drug resistance. Methods In our...