Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

• 主要な著者: Vladan P. Čokić (著者), Olivera Mitrović-Ajtić (著者), Bojana B. Beleslin-Čokić (著者), Dragana Marković (著者), Marijana Buač (著者), Miloš Diklić (著者), Nada Kraguljac-Kurtović (著者), Svetozar Damjanović (著者), Pavle Milenković (著者), Mirjana Gotić (著者), Puri K. Raj (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2015-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT signaling pathway related genes in circulating CD34+ cells of MPNs. Regarding lab...