Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

• Main Authors: Vladan P. Čokić (Author), Olivera Mitrović-Ajtić (Author), Bojana B. Beleslin-Čokić (Author), Dragana Marković (Author), Marijana Buač (Author), Miloš Diklić (Author), Nada Kraguljac-Kurtović (Author), Svetozar Damjanović (Author), Pavle Milenković (Author), Mirjana Gotić (Author), Puri K. Raj (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT signaling pathway related genes in circulating CD34+ cells of MPNs. Regarding lab...