Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis

• Main Authors: Paloma Ruiz-Blázquez (Author), María Fernández-Fernández (Author), Valeria Pistorio (Author), Celia Martinez-Sanchez (Author), Michele Costanzo (Author), Paula Iruzubieta (Author), Ekaterina Zhuravleva (Author), Júlia Cacho-Pujol (Author), Silvia Ariño (Author), Alejandro Del Castillo-Cruz (Author), Susana Núñez (Author), Jesper B. Andersen (Author), Margherita Ruoppolo (Author), Javier Crespo (Author), Carmen García-Ruiz (Author), Luigi Michele Pavone (Author), Thomas Reinheckel (Author), Pau Sancho-Bru (Author), Mar Coll (Author), José C. Fernández-Checa (Author), Anna Moles (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and objectives: Fibrosis contributes to 45% of deaths in industrialized nations and is characterized by an abnormal accumulation of extracellular matrix (ECM). There are no specific anti-fibrotic treatments for liver fibrosis, and previous unsuccessful attempts at drug development have fo...