Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

• मुख्य लेखकों: Corina Becker (लेखक), Michael Boettcher (लेखक), Uwe Muenster (लेखक), Stephanie Loewen (लेखक), Maximilian Lobmeyer (लेखक), Wolfgang Mueck (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SpringerOpen, 2022-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Objective This article describes in vitro and in vivo studies that aimed to further characterize the biopharmaceutical properties and pharmacokinetic (PK) profile of vericiguat and to guide dosing recommendations. Methods Five open-label, phase I studies characterized the biopharmaceutical...