Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

• Главные авторы: Corina Becker (Автор), Michael Boettcher (Автор), Uwe Muenster (Автор), Stephanie Loewen (Автор), Maximilian Lobmeyer (Автор), Wolfgang Mueck (Автор)
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• Опубликовано: SpringerOpen, 2022-11-01T00:00:00Z.
• Предметы: article
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Abstract Objective This article describes in vitro and in vivo studies that aimed to further characterize the biopharmaceutical properties and pharmacokinetic (PK) profile of vericiguat and to guide dosing recommendations. Methods Five open-label, phase I studies characterized the biopharmaceutical...