Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice

• Main Authors: Manuel Blandino-Rosano (Author), Ruy Andrade Louzada (Author), Joao Pedro Werneck- (Author), Camila Lubaczeuski (Author), Joana Almaça (Author), Markus A. Rüegg (Author), Michael N. Hall (Author), Gil Leibowitz (Author), Ernesto Bernal-Mizrachi (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin resistant state. Method: Here, we use mice with het...