Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice

• Автори: Manuel Blandino-Rosano (Автор), Ruy Andrade Louzada (Автор), Joao Pedro Werneck- (Автор), Camila Lubaczeuski (Автор), Joana Almaça (Автор), Markus A. Rüegg (Автор), Michael N. Hall (Автор), Gil Leibowitz (Автор), Ernesto Bernal-Mizrachi (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objective: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin resistant state. Method: Here, we use mice with het...