Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

• Główni autorzy: Qing Li (Autor), Juan Li (Autor), Shuyun Wang (Autor), Jingnan Wang (Autor), Xiaozheng Chen (Autor), Dongmei Zhou (Autor), Yuying Fang (Autor), Aiqin Gao (Autor), Yuping Sun (Autor)
• Format: Książka
• Wydane: BMC, 2020-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed in myeloid innate cells. Recent studies showed that ILT4 was highly expr...