Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

• Main Authors: Qing Li (Author), Juan Li (Author), Shuyun Wang (Author), Jingnan Wang (Author), Xiaozheng Chen (Author), Dongmei Zhou (Author), Yuying Fang (Author), Aiqin Gao (Author), Yuping Sun (Author)
• Format: Book
• Published: BMC, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed in myeloid innate cells. Recent studies showed that ILT4 was highly expr...