Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents

• Main Authors: Juliusz Maksymilian Walczak (Author), Dorota Iwaszkiewicz-Grześ (Author), Michalina Ziomkowska (Author), Magdalena Śliwka-Kaszyńska (Author), Mateusz Daśko (Author), Piotr Trzonkowski (Author), Grzegorz Cholewiński (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The group of 18 new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5'-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis of 14 of them employed uronium-type activ...