Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

• Main Authors: Tanja Padutsch (Author), Maksim Sendetski (Author), Carina Huber (Author), Nathalie Peters (Author), Klaus Pfizenmaier (Author), John R. Bethea (Author), Roland E. Kontermann (Author), Roman Fischer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. Interleukin 2 (IL-2) and tumor necrosis factor (TNF) have been id...