Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

• Autores principales: Tanja Padutsch (Autor), Maksim Sendetski (Autor), Carina Huber (Autor), Nathalie Peters (Autor), Klaus Pfizenmaier (Autor), John R. Bethea (Autor), Roland E. Kontermann (Autor), Roman Fischer (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. Interleukin 2 (IL-2) and tumor necrosis factor (TNF) have been id...