Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

• المؤلفون الرئيسيون: Awol Mekonnen Ali (مؤلف), Haileyesus Adam (مؤلف), Daniel Hailu (مؤلف), Ephrem Engidawork (مؤلف), Rawleigh Howe (مؤلف), Teferra Abula (مؤلف), Marieke J. H. Coenen (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and large predicts variability in 6-mercaptopurine (6-MP) related toxicities. However, some individuals without genetic variants in TPMT still develop toxicity that necessitates 6-MP dose reduction or interruption....