Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

• Главные авторы: Awol Mekonnen Ali (Автор), Haileyesus Adam (Автор), Daniel Hailu (Автор), Ephrem Engidawork (Автор), Rawleigh Howe (Автор), Teferra Abula (Автор), Marieke J. H. Coenen (Автор)
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• Опубликовано: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Предметы: article
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Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and large predicts variability in 6-mercaptopurine (6-MP) related toxicities. However, some individuals without genetic variants in TPMT still develop toxicity that necessitates 6-MP dose reduction or interruption....