Pravastatin Prevents Increases in Activity of Metalloproteinase-2 and Oxidative Stress, and Enhances Endothelium-Derived Nitric Oxide-Dependent Vasodilation in Gestational Hypertension

• Main Authors: Cristal Jesus Toghi (Author), Laisla Zanetoni Martins (Author), Leonardo Lopes Pacheco (Author), Edileia Souza Paula Caetano (Author), Bruna Rahal Mattos (Author), Elen Rizzi (Author), Carlos Alan Dias-Junior (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pre-eclampsia (PE) is a hypertensive disorder of pregnancy and has been associated with placental growth restriction. The pre-eclamptic placenta releases free radicals to maternal circulation, thus increasing oxidative stress. An impaired redox state leads to reduction in circulating nitric oxide (N...