Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition

For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucleic acid, usually RNA. In this work, using molecula...

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Main Authors: Rodrigo Galindo-Murillo (Author), Jack S. Cohen (Author), Barak Akabayov (Author)
Format: Book
Published: Elsevier, 2021-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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