Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition

• Main Authors: Rodrigo Galindo-Murillo (Author), Jack S. Cohen (Author), Barak Akabayov (Author)
• Format: Knjiga
• Izdano: Elsevier, 2021-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucleic acid, usually RNA. In this work, using molecula...