Nitric Oxide-Donating Genistein Prodrug: Design, Synthesis, and Bioactivity on MC3T3-E1 Cells

• Main Authors: Jiepin Wang (Author), Fujun Shang (Author), Ru Jiang (Author), Li Liu (Author), Siwang Wang (Author), Jin Hou (Author), Menglei Huan (Author), Qibing Mei (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To find a more potent alternative with less estrogen-related side effects for hormone replacement therapy, we designed and synthesized a nitric oxide (NO)-releasing prodrug of genistein, named NO-donating genistein (NO-G). The characteristics of NO-G were determined by melting point, NMR spectroscop...