Peg-Grafted Liposomes for L-Asparaginase Encapsulation

• Main Authors: Marina de Souza Guimarães (Author), Jorge Javier Muso Cachumba (Author), Cecilia Zorzi Bueno (Author), Karin Mariana Torres-Obreque (Author), Grace Verónica Ruiz Lara (Author), Gisele Monteiro (Author), Leandro Ramos Souza Barbosa (Author), Adalberto Pessoa (Author), Carlota de Oliveira Rangel-Yagui (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

L-asparaginase (ASNase) is an important biological drug used to treat Acute Lymphoblastic Leukemia (ALL). It catalyzes the hydrolysis of L-asparagine (Asn) in the bloodstream and, since ALL cells cannot synthesize Asn, protein synthesis is impaired leading to apoptosis. Despite its therapeutic impor...