Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

• Main Authors: Amna Khamis (Author), Mickaël Canouil (Author), Afshan Siddiq (Author), Hutokshi Crouch (Author), Mario Falchi (Author), Manon von Bulow (Author), Florian Ehehalt (Author), Lorella Marselli (Author), Marius Distler (Author), Daniela Richter (Author), Jürgen Weitz (Author), Krister Bokvist (Author), Ioannis Xenarios (Author), Bernard Thorens (Author), Anke M. Schulte (Author), Mark Ibberson (Author), Amelie Bonnefond (Author), Piero Marchetti (Author), Michele Solimena (Author), Philippe Froguel (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Genome wide association studies (GWAS) for type 2 diabetes (T2D) have identified genetic loci that often localise in non-coding regions of the genome, suggesting gene regulation effects. We combined genetic and transcriptomic analysis from human islets obtained from brain-dead organ donor...