Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

• Автори: Amna Khamis (Автор), Mickaël Canouil (Автор), Afshan Siddiq (Автор), Hutokshi Crouch (Автор), Mario Falchi (Автор), Manon von Bulow (Автор), Florian Ehehalt (Автор), Lorella Marselli (Автор), Marius Distler (Автор), Daniela Richter (Автор), Jürgen Weitz (Автор), Krister Bokvist (Автор), Ioannis Xenarios (Автор), Bernard Thorens (Автор), Anke M. Schulte (Автор), Mark Ibberson (Автор), Amelie Bonnefond (Автор), Piero Marchetti (Автор), Michele Solimena (Автор), Philippe Froguel (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2019-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objective: Genome wide association studies (GWAS) for type 2 diabetes (T2D) have identified genetic loci that often localise in non-coding regions of the genome, suggesting gene regulation effects. We combined genetic and transcriptomic analysis from human islets obtained from brain-dead organ donor...