Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study

• Príomhchruthaitheoirí: Suchitra Matsukura (Údar), Yuji Nakamura (Údar), Kiyotaka Hoshiai (Údar), Takashi Hayashi (Údar), Tadashi Koga (Údar), Ai Goto (Údar), Koki Chiba (Údar), Nur Jaharat Lubna (Údar), Mihoko Hagiwara-Nagasawa (Údar), Hiroko Izumi-Nakaseko (Údar), Kentaro Ando (Údar), Atsuhiko T. Naito (Údar), Atsushi Sugiyama (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2018-04-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Effects of moxifloxacin on QTc as well as proarrhythmic surrogate markers including J-Tpeakc, Tpeak-Tend and short-term variability (STV) of repolarization were examined by using both standard E14 time-based evaluation and exposure-response modeling. The study was conducted with a single-blind, rand...