Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study

• Asıl Yazarlar: Suchitra Matsukura (Yazar), Yuji Nakamura (Yazar), Kiyotaka Hoshiai (Yazar), Takashi Hayashi (Yazar), Tadashi Koga (Yazar), Ai Goto (Yazar), Koki Chiba (Yazar), Nur Jaharat Lubna (Yazar), Mihoko Hagiwara-Nagasawa (Yazar), Hiroko Izumi-Nakaseko (Yazar), Kentaro Ando (Yazar), Atsuhiko T. Naito (Yazar), Atsushi Sugiyama (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2018-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Effects of moxifloxacin on QTc as well as proarrhythmic surrogate markers including J-Tpeakc, Tpeak-Tend and short-term variability (STV) of repolarization were examined by using both standard E14 time-based evaluation and exposure-response modeling. The study was conducted with a single-blind, rand...