Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR

• Main Authors: Jun-ming Huang (Author), Ran-yue Ren (Author), Yuan Bao (Author), Jia-chao Guo (Author), Wei Xiang (Author), Xing-zhi Jing (Author), Jia Shi (Author), Guo-xiang Zhang (Author), Long Li (Author), Yong Tian (Author), Hao Kang (Author), Feng-jin Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies indicate that uPAR acts a crucial part in cell migration and the modulation of bone homeostasis. As a natural serine protease inhibitor, ulinastatin owns the capacity to reduce proinflammatory factors, downregulate the activation of NF-κB and mitogen-activated protein kinases (MAPKs)...