Development and In Vitro Evaluation of Controlled Release Viagra^® Containing Poloxamer-188 Using Gastroplus^™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

• Main Authors: Mosab Arafat (Author), Muhammad Sarfraz (Author), Salahdein AbuRuz (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Sildenafil is the active substance in Viagra^® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix sys...