Development and In Vitro Evaluation of Controlled Release Viagra^® Containing Poloxamer-188 Using Gastroplus^™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

• Auteurs principaux: Mosab Arafat (Auteur), Muhammad Sarfraz (Auteur), Salahdein AbuRuz (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sildenafil is the active substance in Viagra^® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix sys...