CASK Mediates Oxidative Stress-Induced Microglial Apoptosis-Inducing Factor-Independent Parthanatos Cell Death via Promoting PARP-1 Hyperactivation and Mitochondrial Dysfunction

• Main Authors: Keith Jun Hao Cheong (Author), Duen-Yi Huang (Author), Ponarulselvam Sekar (Author), Rou Jhen Chen (Author), Irene Han-Juo Cheng (Author), Chi-Ming Chan (Author), Yuan-Shen Chen (Author), Wan-Wan Lin (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcium/calmodulin-dependent serine protein kinase (CASK) is a scaffold protein and plays critical roles in neuronal synaptic formation and brain development. Previously, CASK was shown to associate with EGFR to maintain the vulval cell differentiation in <i>C. elegans</i>. In this study...