Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

• Main Authors: McDonald Jay M (Author), Reddy Vishnu (Author), Makris Christopher (Author), Dale Janet K (Author), Zheng Lixin (Author), Atkinson T Prescott (Author), Pan George (Author), Bi Lilia L (Author), Siegel Richard M (Author), Puck Jennifer M (Author), Lenardo Michael J (Author), Straus Stephen E (Author)
• Format: Book
• Published: BMC, 2007-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background:</p> <p>Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; <it>TNFRSF6</it>), a cell surface receptor that regu...