Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways

• Main Authors: Sambucetti Lidia C (Author), Zhu Lingyun (Author), Ahsan Muhammad H (Author), Zhang Ning (Author), Purchio Anthony F (Author), West David B (Author)
• Format: Book
• Published: BMC, 2005-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>IκBα is an inhibitor of the nuclear transcription factor NF-κB. Binding of IκBα to NF-κB inactivates the transcriptional activity of NF-κB. Expression of IκBα itself is regulated by NF-κB, which provides auto-regulation of this signaling pathway. Here we present...