A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects

• Main Authors: Qian Chen (Author), Qingqing Wu (Author), Rong Song (Author), Yating Wang (Author), Mengqi Zhang (Author), Fangqiong Li (Author), Weifang Zeng (Author), Wei Wang (Author), Jingying Jia (Author), Chen Yu (Author), Yanmei Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chinese subjects.Methods: The randomized, double-blind,...