Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model

• Main Authors: Catarina Chaves (Author), Tuan-Minh Do (Author), Céline Cegarra (Author), Valérie Roudières (Author), Sandrine Tolou (Author), Gilbert Thill (Author), Corinne Rocher (Author), Michel Didier (Author), Dominique Lesuisse (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The non-human primate (NHP)-brain endothelium constitutes an essential alternative to human in the prediction of molecule trafficking across the blood-brain barrier (BBB). This study presents a comparison between the NHP transcriptome of freshly isolated brain microcapillaries and in vitro-selected...