Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel

• Κύριοι συγγραφείς: Xiuming Dong (Συγγραφέας), Yani Liu (Συγγραφέας), Heling Niu (Συγγραφέας), Gongxin Wang (Συγγραφέας), Liying Dong (Συγγραφέας), Anruo Zou (Συγγραφέας), KeWei Wang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-07-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for the type 2 form of long QT syndrome in patien...