Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel

• Main Authors: Xiuming Dong (Author), Yani Liu (Author), Heling Niu (Author), Gongxin Wang (Author), Liying Dong (Author), Anruo Zou (Author), KeWei Wang (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for the type 2 form of long QT syndrome in patien...