Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins

• Principais autores: Yan Zhao (Autor), Haolin Jiang (Autor), Hang Chen (Autor), Jiazhen Yu (Autor), Luyao Wang (Autor), Wen Zhou (Autor), Juanjuan Du (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2024-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Intracellular delivery of biologicals such as peptides, proteins, and nucleic acids presents a great opportunity for innovative therapeutics. However, the endosome entrapment remains a major bottleneck in the intracellular delivery of biomacromolecules, largely limiting their therapeutic potential....