Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins

Intracellular delivery of biologicals such as peptides, proteins, and nucleic acids presents a great opportunity for innovative therapeutics. However, the endosome entrapment remains a major bottleneck in the intracellular delivery of biomacromolecules, largely limiting their therapeutic potential....

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Main Authors: Yan Zhao (Author), Haolin Jiang (Author), Hang Chen (Author), Jiazhen Yu (Author), Luyao Wang (Author), Wen Zhou (Author), Juanjuan Du (Author)
Format: Book
Published: Elsevier, 2024-10-01T00:00:00Z.
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