Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

• Κύριοι συγγραφείς: Fabrice E Graf (Συγγραφέας), Philipp Ludin (Συγγραφέας), Tanja Wenzler (Συγγραφέας), Marcel Kaiser (Συγγραφέας), Reto Brun (Συγγραφέας), Patient Pati Pyana (Συγγραφέας), Philippe Büscher (Συγγραφέας), Harry P de Koning (Συγγραφέας), David Horn (Συγγραφέας), Pascal Mäser (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Tryp...