Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

• Main Authors: Fabrice E Graf (Author), Philipp Ludin (Author), Tanja Wenzler (Author), Marcel Kaiser (Author), Reto Brun (Author), Patient Pati Pyana (Author), Philippe Büscher (Author), Harry P de Koning (Author), David Horn (Author), Pascal Mäser (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Tryp...