Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury

• Main Authors: Corry D. Bondi (Author), Brittney M. Rush (Author), Hannah L. Hartman (Author), Jiaxuan Wang (Author), Mohammad M. Al-Bataineh (Author), Rebecca P. Hughey (Author), Roderick J. Tan (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic kidney disease (CKD) progression, but we previously de...