Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury

• Autori principali: Corry D. Bondi (Autore), Brittney M. Rush (Autore), Hannah L. Hartman (Autore), Jiaxuan Wang (Autore), Mohammad M. Al-Bataineh (Autore), Rebecca P. Hughey (Autore), Roderick J. Tan (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic kidney disease (CKD) progression, but we previously de...