Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation

• Автори: Jordan T. Brooks (Автор), Ron J. Keizer (Автор), Janel R. Long-Boyle (Автор), Sandhya Kharbanda (Автор), Christopher C. Dvorak (Автор), Brian D. Friend (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: With a notably narrow therapeutic window and wide intra- and interindividual pharmacokinetic (PK) variability, initial weight-based dosing along with routine therapeutic drug monitoring of tacrolimus are employed to optimize its clinical utilization. Both supratherapeutic and subtherapeu...