Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation

Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation

Background: With a notably narrow therapeutic window and wide intra- and interindividual pharmacokinetic (PK) variability, initial weight-based dosing along with routine therapeutic drug monitoring of tacrolimus are employed to optimize its clinical utilization. Both supratherapeutic and subtherapeu...

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Main Authors: Jordan T. Brooks (Author), Ron J. Keizer (Author), Janel R. Long-Boyle (Author), Sandhya Kharbanda (Author), Christopher C. Dvorak (Author), Brian D. Friend (Author)
Format: Book
Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
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